Studies

MCRN adoption

GMLC can only support studies that have been adopted by the MCRN. The MCRN supports a variety of different types of research study including quantitative and qualitative projects that are both commercially and non-commercially funded and/or sponsored. To be adopted, studies must have:

  • Adequate peer review
  • Funding awarded in open and national competition
  • Be related to medicines in some way

Details of the current MCRN portfolio can be found at the UKCRN Clinical Research Portfolio.

Visit the MCRN website for information on getting studies adopted onto the portfolio, or contact our Network Manager, Sarah Rickard.

GMLC Study Portfolio

Please contact GMLC Manager Sarah Rickard for details on how to get involved in an MCRN study and what GMLC support may be available.

Below is a list of MCRN studies currently being supported by GMLC.

 To see our list of Paediatric Non-Medicines Research (PNMR) studies please click here

Medicines for Children Research Portfolio

 

Acronym Study title Site PI Study status Comments
AdDIT Adolescent Type 1 Diabetes cardio-Renal Intervention Trial        
    Royal Manchester Children's Hospital Amin,  Dr Rakesh Open  
    Stepping Hill Hospital Cooper,  Dr Chris Open  
ADDRESS After Diagnosis Diabetes Research Support System        
    Royal Manchester Children's Hospital Doughty, Dr ian Open  
    Royal Preston Hospital Foster, Dr Melanie Open  
    Stepping Hill Hospital Cooper, Dr Chris In set-up  
    Rochdale Infirmary Ariyawansa, Dr Indra Open  
    Wythenshawe Hospital Riddle, Dr Miles Open  
    Pendleton Gateway Centre Kannan, Dr Swaminathan In set-up  
    Blackpool Victoria Hospital Mohanty, Dr Rabin In set-up  
    Royal Oldham Hospital Odeka, Dr Egware Open  
    Royal Albert Edward Infirmary Robinson, Dr Mark Open  
    Royal Blackburn Hospital Smith, Dr Claire Open  
    Burnley General Hospital Smith, Dr Claire Open  
    Tameside General Hospital Tatnall, Dr Sarah In set-up  
    North Manchester General Hospital Bagewadi, Dr Sunil In set-up  
BOOST II UK Which oxygen saturation level should we use for very premature infants? A randomised controlled trial        
    Salford Royal Hospital Settle,  Dr Paul Open  
    Bradford Royal Infirmary Oddie, Dr Sam Open  
    Leeds General Hospital Miall, Dr Lawrence Open  
CATCH A randomised controlled trial comparing the effectiveness of heparin bonded or antibiotic impregnated central venous catheters with standard conetral venous catheters for the prevention of hospital acquired blood stream infection in children        
    Leeds General Infirmary Roche, Dr John In Set-up  
CHiP Trial Control of Hyperglycaemia in Paediatric Intensive Care: The CHIP Trial        
    Royal Manchester Children's Hospital Fortune,  Dr Peter-Marc Open  
CHIPS (HIV) HIV registry        
    Blackpool Victoria Hospital Laycock,  Dr Nigel Open  
    Royal Preston Hospital O'Connor, Dr Ruth Open  
    North Manchester General Hospital Tan,  Dr Anton Open  
    Halliwell Children's Centre Ainley-Walker, Dr P Open  
    Calderdale General Hospital Sharpe, Dr Gill Open  
DEPICTED Development and Evaluation of a Psychosocial Intervention for Children and Teenagers Experiencing Diabetes        
    Royal Blackburn Hospital Smith,  Dr Claire Open  
   

Royal Manchester Children's Hospital

Bone,  Dr Mark Open  
    St Mary's Hospital Marshall,  Ms Marie Open  
    St James's University Hospital Campbell, Dr Fiona Open  
DETEMIR The comparison of the effects of insulin Detemir with insulin Glargine on weight gain in female adolescents and young adults with Type 1 Diabetes on a basal bolus regime        
    Stepping Hill Hospital Cooper,  Dr Chris Open  
    Royal Bolton Hospital Sankar,  Dr Vengudi Open  
    Royal Blackburn Hospital   Open  
EMSC Validation of early morning salivary cortisol (EMSC) as a non-invasive, patient friendly, reliable, cost effective measure of adrenal reserve in children receiving inhaled corticosteroids        
    North Manchester General Hospital Dasgupta, Dr Suparna Open  
    Royal Manchester Children's Hospital Murray,  Dr Clare Open  
    Royal Blackburn Hospital Robertson, Dr Tanya Open  
    Royal Preston Hospital Mahmood, Dr Dhia Open  
    Royal Albert Edward Infirmary Shenoy, Dr Anil Open  
EPIC Evidence into practice: Evaluating a child centred intervention for diabetes medicine management        
    Royal Bolton Hospital Sankar, Dr Vengudi Open  
Growth Hormone QoL Growth Hormone Quality of Life Study        
    Royal Manchester Children's Hospital Hall,  Dr Catherine Open  
HIVAT Assessing the impact and safety of home intravenous antibiotic treatment (IVAT) for children with cystic fibrosis        
    Blackpool Victoria Hospital Rowlands, Dr Ned Open  
    Royal Albert Edward Infirmary Shenoy,  Dr Anil Open  
    Wythenshawe Hospital Rao, Dr Naveen Open  
    Royal Preston Hospital Sugumar, Dr K Open  
I2S2 A randomised control trial of iodine supplementation in preterm infants        
    Stepping Hill Hospital Heal, Dr Carrie In set-up  
    Royal Bolton Hospital Yadav, Dr Mahesh In Set-up  
ICISS The International Collaborative Infantile Spasms Study: A randomised trial in the medicinal treatment of infantile spasms        
    Royal Oldham Hospital Prakash,  Dr Nandhini Open  
    Trafford General Hospital Lewis,  Dr Helen Open  
    Royal Preston Hospital De Goede,  Dr Christian Open  
    Rochdale Infirmary Rifkin,  Dr Robin Open  
    Royal Bolton Hospital Hindley,  Dr Dan Open  
    Royal Blackburn Hospital Rakshi,  Dr Karl Open  
    Burnley General Hospital  Bamford, Dr Nicola Open  
    Blackpool Victoria Hospital Thomas,  Dr Megan Open  
    Fairfield General Hospital Levy,  Dr Rob Open  
    Royal Manchester Children's Hospital Newton,  Dr Richard Open  
    Furness General Hospital Olabi,  Dr Anas Open  
    Wythenshawe Hospital Yeung, Dr Lap   Open  
    Royal Albert Edward Infirmary Velmuguran,  Dr Singara Open  
    Stepping Hill Hospital Houston, Dr Erica In Set-up  
    Halliwell Children's Centre Hindley, Dr Dan Open  
    Airedale General Hospital Bala, Dr Pronab In Set-up  
    Royal Lancaster Infirmary Gibson, Dr Paul In set-up  
    Leeds General Infirmary Ferrie, Dr Colin In set-up  
    Bradford Royal Infirmary Ginbey, Dr Des In set-up  
    Huddersfield Royal Infirmary Hamilton, Dr Alex In set-up  
JDCBR Juvenile Dermatomyositis cohort Biomarker Study and Repository (UK & Ireland)        
    Royal Manchester Children's Hospital Riley, Dr Phil Open  
JUMP Type 2 Diabetes in Childhood: Building a platform for interventions to prevent the progression to cardiovascular disease        
    Royal Manchester Children's Hospital Ehtisham, Dr Sarah In Set-up  
    Bradford Royal Infirmary Gorman, Dr Shaun Open  
    Huddersfield Royal Infirmary Terrett, Dr Lynne Open  
    Leeds General Infirmary Holland, Dr Philip In Set-up  
KICk-OFF Kids In Control OF Food: A mulit-centre, cluster randomised controlled trial comparing structured education (the KICk-OFF course) with standard care in 11-16 year olds with Type 1 Diabetes (T1DM)  on intensive insulin therapy        
    Royal Manchester Children's Hospital Doughty, Dr Ian Open  
    Salford Royal Hospital Kannan, Dr Swaminathan Open  
    Burnley General Hospital Smith, Dr Claire Open  
KKR Teaching parents to become home-based car-givers of children's long term kidney conditions: a mixed methods study in all UK Children's Kideney Units.        
    Royal Manchester Children's Hospital Webb, Dr Nick Open  
    St James' Hospital, Leeds Feather, Dr Sally Open  
LYSOSOMAL STORAGE DISORDERS Proposal to conduct long term cohort study of people with lysosomal storage disorders        
    Royal Manchester Children's Hospital Wraith,  Dr Ed Open  
MAGNETic A randomised controlled trial of nebulised magnesium in acute severe asthma in children        
    Royal Albert Edward Infirmary Shenoy,  Dr Anil Open  
    Tameside General Hospital Levy,  Dr David Open  
    Blackpool Victoria Hospital Goldberg,  Dr Kate Open  
    Royal Preston Hospital Mahmood,  Dr Dhia Open  
    Wythenshawe Hospital Al-Zidgali,  Dr Faisal Open  
    Royal Manchester Children's Hospital Potier, Dr Katherine Open  
MCRN026 Hypertension Study Commercial hypertension study        
    Royal Manchester Children's Hospital Webb,  Dr Nick Open  
MCRN027 Zoledronic Acid Study Commercial Zoledronic Acid Study        
    Royal Manchester Children's Hospital Mugal, Dr Zulf In set-up  
MCRN030 MPS Assessment Study Commercial MPS assessment study        
    Royal Manchester Children's Hospital Jones, Dr Simon Open  
MCRN031 MPS Trial Commercial MPS Trial        
    Royal Manchester Children's Hospital Jones, Dr Simon Open  
MCRN043 Eltrombopag/ITP Commercial ITP Trial        
    Royal Manchester Children's Hospital Grainger, Dr John Open  
MCRN046 MPS VI CSP MPS VI Clinical Surveillance Program        
    Royal Manchester Children's Hospital Wraith, Dr Ed Open  
MCRN050 Sickle Cell Commercial Sickle Cell Study        
    Royal Manchester Children's Hospital Will, Dr Andrew Open  
MCRN057 Commercial Respiratory Study        
    Wythenshawe Hospital Custovic, Prof Adnan Open  
MCRN058 Commercial Hunter Syndrome Study        
    Royal Manchester children's Hospital Wraith, Dr Ed Open  
MCRN063 Commercial Hypertension Study        
    Royal Manchester Childnre's Hospital Webb, Dr Nick Open  
MCRN065 Commercial Tamiflu Study        
    Blackpool Victoria Hospital Thomas, Dr Megan In set-up   
    Royal Albert Edward Infirmary Shenoy, Dr Anil In set-up  
    Royal Preston Hospital Sugumar, Dr Karnam In set-up  
    Leeds Teaching Hospitals Tust Thethy, Dr Ragbir In set-up  
MCRN067 Commercial JIA Study        
    Royal Manchester Children's Hospital Chieng, Dr Alice Open  
MCRN068 Commercial JIA Study        
    Royal Manchester Children's Hospital Chieng, Dr Alice Open  
MCRN069 Commercial JIA Study        
    Royal Manchester Children's Hospital Chieng, Dr Alice Open  
MCRN071 Commercial Migraine Study        
    Airedale General Hospital Bala, Dr Pronab Open  
MCRN075 Commercial MMA Study        
    Royal Manchester Children's Hospital Morris, Dr Andrew In set-up  
MCRN078 Commercial Epilepsy Study        
    Leeds General Infirmary Ferrie, Dr Colin Open  
MCRN081 Commercial MPSIIIA Study        
    Royal Manchester Children's Hospital Jones, Dr Simon Open  
MCRN088 Commercial Renal Study        
    Royal Manchester Children's Hospital Webb, Dr Nick In set-up  
MCRN091 Commercial GERD study        
    Royal Preston Hospital Gupta, Dr Richa In set-up  
MENDS The use of melatonin in children with neurodevelopmental disorders and impaired sleep: an RCT        
    Royal Manchester Children's Hospital Martland,  Dr Tim Open  
    Blackpool Victoria Hospital Thomas, Dr Megan Open  
METABOLOME A pilot study to assess the use of metabolome profiling in the management of the child born small for gestational age.       Open at tertiary centre and seeking referrals. Contact gmlc@mcrn.org.uk for details 
    Stepping Hill Hospital Cooper,  Dr Chris Open  
    Royal Oldham Hospital Padmakumar,  Dr Beena Open  
    St Mary's Hospital Victor,  Dr Suresh Open  
    Royal Bolton Hospital Powell,  Dr Peter Open  
    Rochdale Infirmary Odeka,  Dr Egware Open  
    Salford Royal Hospital Settle,  Dr Paul Open  
    Fairfield General Hospital Odeka,  Dr Egware Open  
    North Manchester General Hospital Odeka,  Dr Egware Open  
    Royal Manchester Children's Hospital Clayton,  Professor Peter Open  
    Tameside General Hospital Birch, Dr Jackie Open  
    Royal Albert Edward Infirmary Shenoy,  Dr Anil Open  
MIND Melatonin As A Novel Neuroprotectant
In Preterm Infants- Dosage Study
       
    Royal Bolton Hospital Yadav, Dr Mahesh Open  
    Salford Royal Hospital Maddock, Dr Natasha Open  
    Stepping Hill Hospital Heal, Dr Carrie Open  
    Royal Preston Hospital Gupta, Dr Richa Open  
MPGN National study of membranoproliferative glomerulonephritis        
    Royal Manchester Children's Hospital Webb, Dr Nick In set-up  
    Leeds General Infirmary Fitzpatrick, Dr Maggie In set-up  
MYCYC A randomised clinical trial of mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA associated vasculitis        
    Royal Manchester Children's Hospital Webb,  Dr Nick Open  
NFS Diabetic Nephropathy General analysis of risk factors for the develpoment of diabetic complications        
    Stepping Hill Hospital Cooper, Dr Chris Open  
    Royal Manchester Children's Hospital Bone, Dr Mark Open  
    Pendleton Centre Kannan, Dr Swaminathan Open  
P3MC A double blind parallel group randomised placebo controlled trial of Propranolol and Pizotifen in preventing migraine in children        
    Royal Manchester Children's Hospital Newton,  Dr Richard Open  
PASS Pharmacogenetics of Adrenal Suppression with Inhaled Steriods        
    Royal Blackburn Hospital Robertson, Dr Tanya Open  
    North Manchester General Hospital Dasgupta, Dr Suparna Open  
    Royal Manchester Children's Hospital Murray, Dr Clare Open  
    Royal Preston Hospital Mahmood, Dr Dhia Open  
    Royal Albert Edward Infirmary Shenoy, Dr Anil Open  
    St Luke's Hospital, Bradford Moya, Dr Eduardo Open  
    Leeds General Infirmary Lee, Dr Tim Open  
    Furness General Hospital Olabi, Dr Anas Open  
    Tameside General Hospital Levy, Dr David In set-up  
    Stepping Hill Hospital Cooper, Dr Chis In set-up  
    Royal Oldham Hospital Dasgupta, Dr Suparna Open  
PENTA18 A study of the pharmacokinetics, safety and efficacy of twice-daily versus once-daily lopinavir/ritonavir tablets dosed by weight as part of combnination antiretroviral therapy in HIV-1 infected children        
    North Manchester General Hospital Tan, Dr Anton In Set-up  
POP Prevention and treatment of steriod-induced osteopaenia in children and adolescents with rheumatic diseases        
    Leeds General Infirmary Wood, Dr Mark Open  
    Royal Manchester Children's Hospital Chieng, Dr Alice Open  
PUDDLS A prospective UK study of the clinical features and outcome of children with CNS demyelinating disease        
    Royal Preston Hospital De Goede, Dr Christian Open  
PUPS A phase IV study to evaluate the primary and booster immune responses of UK preterm infants receiving licensed DTaP/Hib/IPV and meningococcal C conjugate vaccine and incorporating a randomisation study of a 3 dose accelerated versus a 2 dose and a 3 dose extended schedule of pneumococcal conjugate vaccine for primary immunisation        
    Stepping Hill Hospital Baxter, Dr David In Set-up  
    Salford Royal Hospital Robinson, Dr Mike In Set-up  
RADAR National Studies of Kidney Disease in Childhood and Adolescence        
    Royal Manchester Children's Hospital Webb, Dr Nick Open  
    St James' University Hospital Fitzpatrick, Dr Maggie Open  
Salford Bright Smiles A comparison of community based preventive services to improve child dental health        
    Salford PCT Pine, Dr Cynthia In set-up  
SLEEPS Safety profile, efficacy and equivalence in paediatric intensive care sedation        
    Royal Manchester Children's Hospital Playfor,  Dr Stephen Open  
    Leeds General Infirmary Haywood, Dr Tim In Set-up  
Steroid Resistant Nephrotic Syndrome National Study of Steroid Resistant Nephrotic Syndrome in Childhood        
    Royal Manchester Children's Hospital Webb, Dr Nick Open  
    Leeds General Infirmary Feather. Dr Sally Open  
Thyrotoxicosis A randomised study of two antithyroid drug treatment regimens in young people with thyrotoxicosis        
    Royal Manchester Children's Hospital Ehtisham, Dr Sarah Open  
TORPEDO-CF Trial of Optimal Therapy for Pseudomonas Eradication in Cystic Fibrosis        
    St James' University Hospital Lee, Dr Tim In Set-up  
UK JSLE COHORT STUDY AND REPOSITORY UK JSLE Cohort Study and Repository UK Juvenile-onset Systemic Lupus Erythematosis Cohort Study & Repository: Clinical Characteristics and Immunopathology of Juvenile-onset SLE        
    Royal Manchester Children's Hospital Riley,  Dr Phil Open  
Variability in response to Warfarin in Children Inter-individual Variability in response to Warfarin in Children: Analysis of Environmental and Pharmacogenetic Factors        
    Royal Manchester Children's  Hospital Grainger, Dr John Open